| Autor: |
Wenzhi, Yuan, Yanjun, Wu, Zhibin, Zhang, Guochao, Shi, Wei, Han, Kuihua, Li, Jungai, Gu, Congzhe, Chen, Jialin, Ge, Wenying, Zhou, Jiahao, Cui, Mingli, Wang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Optics Express. 30:38613 |
| ISSN: |
1094-4087 |
| DOI: |
10.1364/oe.474108 |
| Popis: |
The combination of new noble metal nanomaterials and surface enhanced Raman scattering (SERS) technology has become a new strategy to solve the problem of low sensitivity in the detection of traditional Chinese medicine. In this work, taking natural cicada wing (C.w.) as a template, by optimizing the magnetron sputtering experimental parameters for the growth of Ag nanoparticles (NPs) on vanadium-titanium (V-Ti) nanorods, the nanogaps between the nanorods were effectively regulated and the Raman signal intensity of the Ag15/V-Ti20/C.w. substrate was improved. The proposed homogeneous nanostructure exhibited high SERS activity through the synergistic effect of the electromagnetic enhancement mechanism at the nanogaps between the Ag NPs modified V-Ti nanorods. The analytical enhancement factor (AEF) value was as high as 1.819 × 108, and the limit of detection (LOD) was 1 × 10−11 M for R6G. The large-scale distribution of regular electromagnetic enhancement “hot spots” ensured the good reproducibility with the relative standard deviation (RSD) value less than 7.31%. More importantly, the active compound of Artemisinin corresponded the pharmacological effect of Artemisia annua was screened out by SERS technology, and achieved a LOD of 0.01 mg/l. This reliable preparation technology was practically applicable to produce SERS-active substrates in detection of pharmacodynamic substance in traditional Chinese medicine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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