TNF-α and IL10 gene polymorphisms in women with postmenopausal osteoporosis
| Autor: | Andrzej Pawlik, Zygmunt Juzyszyn, Krzysztof Safranow, Daniel Kotrych, Violetta Dziedziejko, Tomasz Sroczynski, Marzena Staniszewska |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Genotype Bone density Osteoporosis Polymorphism Single Nucleotide Bone resorption Bone remodeling Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Gene Frequency Bone Density Osteoclast Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease Allele frequency Alleles Osteoporosis Postmenopausal Aged Tumor Necrosis Factor-alpha business.industry Obstetrics and Gynecology Middle Aged medicine.disease Interleukin-10 Postmenopause 030104 developmental biology Endocrinology medicine.anatomical_structure Reproductive Medicine 030220 oncology & carcinogenesis Female business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 199:92-95 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2016.01.037 |
| Popis: | Objective Postmenopausal osteoporosis is a common disorder characterized by decreased bone mineral density (BMD). Proinflammatory cytokines are among the significant factors involved in bone turnover. They are the stimulants of bone resorption, acting directly on osteoclasts and osteoclast precursors. In this study, we examined the TNF-α (−308G>A) (rs1800629) and IL10 (−1082G>A) (rs1800896), (−592C>A) (rs1800872) polymorphisms in postmenopausal women with BMD T -scores less than and greater than or equal to −2.5 SD. Study design This study included 224 postmenopausal women with BMD T -scores lower than −2.5 SD (mean: −3.02±0.53) and 238 postmenopausal women with BMD T -scores −2.5 SD and greater (mean: −1.33±0.51). Results There was a decrease in the frequency of IL10 1082 G allele carriers (GG and GA genotypes) in women with T -scores below −2.5 SD (GG+GA vs AA: OR=0.65, 95% CI=0.44−0.97, p =0.037). With regard to the TNF-α −308 G>A polymorphism, in the women with T -scores below −2.5 SD, the increased frequency of GG homozygotes and G allele carriers was detected (AA+GA vs GG: OR=0.54, 95% CI=0.35−0.82, p =0.004). Conclusions The results of our study suggest an association between TNF-α −308G>A and IL10 −1082G>A polymorphisms and postmenopausal osteoporosis. |
| Databáze: | OpenAIRE |
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