Self-administration of methionine enkephalin into the nucleus accumbens
| Autor: | John D. Lane, Nicholas E. Goeders, James E. Smith |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Microinjections Enkephalin Substance-Related Disorders Enkephalin Methionine Clinical Biochemistry Neuropeptide Self Administration Nucleus accumbens Stimulus (physiology) Toxicology Biochemistry Nucleus Accumbens Behavioral Neuroscience Receptors Opioid delta Internal medicine Basal ganglia medicine Animals Humans Biological Psychiatry Pharmacology Behavior Animal Dose-Response Relationship Drug Naloxone Chemistry Rats Inbred F344 Rats Ventral tegmental area Endocrinology medicine.anatomical_structure Opioid Receptors Opioid Septal Nuclei Opiate Neuroscience medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 20:451-455 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(84)90284-3 |
| Popis: | Microinfusions of the endogenous opiate neurohumor, methionine enkephalin, into the nucleus accumbens initiated a reinforcing stimulus in a dose-related manner. The reinforcing nature of this intracranial self-administration was evaluated with intermittent schedules of reinforcement and a two-lever discrimination procedure. Opiate receptors are likely responsible for the initiation of this reinforcing stimulus since naloxone effectively blocked self-administration. These data suggest the mediation of opiate reinforcement through interactions with opiate receptors in brain regions outside the ventral tegmental area, questioning the current dopamine hypothesis for the initiation of these reinforcement processes. |
| Databáze: | OpenAIRE |
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