Serum levels of IGFBP7 are elevated during acute exacerbation in COPD patients
| Autor: | Minliang Wu, Wenjing Ruan, Xiaohong Wu, Fengying Li, Liangliang Dong, Yuanhua Qiu, Kejing Ying, Liuhong Shi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Time Factors Exacerbation 030204 cardiovascular system & hematology Gastroenterology law.invention Pulmonary Disease Chronic Obstructive 0302 clinical medicine Patient Admission law Lung media_common Original Research Aged 80 and over Immunoassay COPD biology Convalescence Area under the curve General Medicine Intensive care unit Patient Discharge Up-Regulation Insulin-Like Growth Factor Binding Proteins C-Reactive Protein Area Under Curve Disease Progression Population study biomarker Female medicine.medical_specialty media_common.quotation_subject International Journal of Chronic Obstructive Pulmonary Disease 03 medical and health sciences Predictive Value of Tests Internal medicine medicine Humans acute exacerbation Aged business.industry C-reactive protein Case-control study Reproducibility of Results medicine.disease 030228 respiratory system ROC Curve Case-Control Studies biology.protein IGFBP7 business serum Biomarkers |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 1176-9106 |
| Popis: | Wenjing Ruan,1 Minliang Wu,2 Liuhong Shi,1 Fengying Li,3 Liangliang Dong,1 Yuanhua Qiu,1 Xiaohong Wu,1 Kejing Ying1 1Department of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 2Department of Laboratory, The Second Affiliated Hospital of Zhejiang University, School of Medicine, 3Department of Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Hangzhou, China Objective: The purpose of this study was to explore the insulin-like growth factor binding protein 7 (IGFBP7) level in the serum of chronic obstructive pulmonary disease (COPD) patients during acute exacerbation (AE).Methods: The study population consisted of 47 AECOPD patients, including 25 patients enrolled between January 2011 and February 2011 (the first group) and 22 patients enrolled from December 2011 to August 2012 (the second group) and 29 healthy controls. Chemiluminescence–linked immunoassay was used to detect serum IGFBP7 levels. For the second group patients, IGFBP7 and C-reactive protein (CRP) levels were measured both on the admission day and on the discharge day.Results: Among the first group AECOPD patients, serum IGFBP7 levels were significantly elevated in AECOPD patients in the intensive care unit (ICU; 52.92±16.32 ng/mL), and in hospitalized AECOPD patients not in ICU (40.66±13.9), compared to healthy subjects (30.3±7.09ng/mL; P |
| Databáze: | OpenAIRE |
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