A reexamination of the effect of exercise on rate of muscle protein degradation
| Autor: | George J. Kasperek, J. J. Lohne, Gordon Conway, D. S. Krayeski |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Physiology Endocrinology Diabetes and Metabolism Muscle Proteins Physical exercise Protein degradation Biology Motor Activity Rats Sprague-Dawley Physiology (medical) Internal medicine medicine Animals Muscle protein Skeletal muscle Chloroquine Metabolism Methylhistidines Electric Stimulation Rats medicine.anatomical_structure Endocrinology Degradation (geology) Tyrosine medicine.symptom Myofibril Lysosomes Muscle contraction Muscle Contraction |
| Zdroj: | The American journal of physiology. 263(6) |
| ISSN: | 0002-9513 |
| Popis: | The purpose of this study was to examine the effect of exercise on the rate of protein degradation in rat skeletal muscle. The rates of total and myofibrillar protein degradation were determined by the measurement of the rates of release of tyrosine and 3-methylhistidine, respectively, from the perfused single rat leg. This method measures the rate of protein degradation in the entire lower leg and does not suffer from the limitations inherent in methods that rely on urinary excretion. The rate of total protein degradation was increased by exercise and involved increased flux through the lysosomal pathway, while the breakdown of myofibrillar protein was unchanged. The changes in the rates of protein degradation during the recovery period were greatly influenced by energy intake. Again the rate of myofibrillar protein degradation was unchanged or slightly increased during the recovery period, after either level or downgrade running. Exercise did prevent the increase in the rate of total protein degradation caused by food restriction, which may have important implications in weight reduction diets. |
| Databáze: | OpenAIRE |
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