Crohn’s disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants
| Autor: | Kostas Masalas, Michael Economou, Antonios Kogevinas, Zoi Tsianou, Epameinondas V. Tsianos, John Alamanos, Grigoris Filis, Anna Petrou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Mutation/genetics Adolescent Nod2 Signaling Adaptor Protein Greece/epidemiology Disease Gastroenterology Inflammatory bowel disease Annual incidence Crohn Disease Crohn Disease/*epidemiology/ethnology/*genetics Nod2 Signaling Adaptor Protein/*genetics Internal medicine NOD2 Epidemiology medicine Humans Genetic Predisposition to Disease Aged Aged 80 and over Crohn's disease Greece business.industry Genetic Predisposition to Disease/genetics Incidence (epidemiology) Incidence General Medicine Middle Aged medicine.disease Ulcerative colitis digestive system diseases Immunology Mutation Colitis Ulcerative/epidemiology/genetics Colitis Ulcerative Female business Rapid Communication |
| Popis: | AIM: To assess the trends in the incidence of inflammatory bowel disease (IBD) over 23 years in the same area and to identify genetic factors related to incidence evolution. METHODS: Patients with IBD arising from North-western Greece were systematically recorded through the 1983-2005 period. Trends in disease incidence and genetic patterns related to CARD15 variants were documented and correlated. RESULTS: A total of 447 patients with IBD were recorded (23.5% Crohn's disease, 72.7% Ulcerative colitis and 3.8% indeterminate colitis). Mean annual incidence rates of CD and UC were 0.9/100,000 (95% CI 0.1-1.7) and 2.7/100,000 (95% CI 1.7-4.1) inhabitants, respectively. There was a statistically significant increase of CD incidence (P |
| Databáze: | OpenAIRE |
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