Parasite Tolerance and Host Competence in Avian Host Defense to West Nile Virus
| Autor: | Sarah C. Burgan, Stephanie S. Gervasi, Lynn B. Martin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0106 biological sciences 0301 basic medicine West Nile virus Parasitic Diseases Animal Health Toxicology and Mutagenesis medicine.medical_treatment Disease Biology medicine.disease_cause 010603 evolutionary biology 01 natural sciences Interferon-gamma 03 medical and health sciences Interferon medicine Animals Parasite hosting Disease Resistance Ecology Bird Diseases Cytokine expression Viral Load Interleukin-10 030104 developmental biology Cytokine Animal ecology Immunology Cytokines Female Immunocompetence Viral load Biomarkers Sparrows medicine.drug |
| Zdroj: | EcoHealth. 15:360-371 |
| ISSN: | 1612-9210 1612-9202 |
| Popis: | Competence, or the propensity of a host to transmit parasites, is partly underlain by host strategies to cope with infection (e.g., resistance and tolerance). Resistance represents the ability of hosts to prevent or clear infections, whereas tolerance captures the ability of individuals to cope with a given parasite burden. Here, we investigated (1) whether one easy-to-measure form of tolerance described well the dynamic relationships between host health and parasite burden, and (2) whether individual resistance and tolerance to West Nile virus (WNV) were predictable from single cytokine measures. We exposed house sparrows (HOSP) to WNV and measured subsequent changes in host performance, viral burden, and cytokine expression. We then used two novel approaches (one complex, one simpler) to estimate tolerance within-individual HOSP using four separate host performance traits. We lastly investigated changes in the expression of pro-inflammatory cytokine interferon-γ (IFN-γ) and anti-inflammatory cytokine interleukin-10 (IL-10). Both approaches to estimating tolerance were equivalent among WNV-infected HOSP; thus, an easy-to-measure tolerance estimation may be successfully applied in field studies. Constitutive expression of IFN-γ and IL-10 were predictive of resistance and tolerance to WNV, implicating these cytokines as viable biomarkers of host competence to WNV. |
| Databáze: | OpenAIRE |
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