LncRNA SNHG25 Promotes Glioma Progression Through Activating MAPK Signaling

Autor:	Zeyu Wu, Peng Lun, Tao Ji, Jiaojiao Niu, Xiuyan Sun, Xia Liu, Jian Xu
Rok vydání:	2022
Předmět:	Gene Expression Regulation Neoplastic Cellular and Molecular Neuroscience MicroRNAs Neurology Cell Line Tumor Neuroscience (miscellaneous) Humans RNA Long Noncoding Glioma Sincalide Cell Proliferation
Zdroj:	Molecular neurobiology. 59(11)
ISSN:	1559-1182
Popis:	Numerous studies indicated that long non-coding RNAs (lncRNAs) play critical roles in glioma initiation and progression. SNHG25 is a newly identified lncRNA. And the functional role and molecular mechanism of SNHG25 in glioma cells have not been investigated. In this study, we found that SNHG25 was upregulated in glioma cells and tissues. CCK-8, EDU, and colony formation assays demonstrated that SNHG25 knockdown markedly inhibited glioma cell proliferation. In vivo studies showed that SNHG25 knockdown significantly inhibited tumor growth. Further studies indicated that SNHG25 positively regulated MAP2K2 through sponging miR-579-5p. High expression of SNHG25 activated MAPK signaling through MAP2K2. These data suggest that SNHG25 is a potential target and biomarker for glioma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26cdffc24f661afc6e5d317dc7bf5b9 https://pubmed.ncbi.nlm.nih.gov/36071306 Zobrazit plný text záznamu Full text from SpringerLink