Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy
| Autor: | Clara Isabel González, F. David Carmona, Daniel A Leon Rodriguez, Javier Martín |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Chagas disease Adult Male Risk Genotype Trypanosoma cruzi Population Biology Colombia Calcitriol receptor Polymorphism Single Nucleotide Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Immune system Gene Frequency medicine Vitamin D and neurology Homeostasis Humans Chagas Disease Genetic Predisposition to Disease Allele education Allele frequency Alleles Aged education.field_of_study Multidisciplinary Middle Aged medicine.disease biology.organism_classification 030104 developmental biology Immunology Receptors Calcitriol Regression Analysis Female Cardiomyopathies 030215 immunology |
| Zdroj: | Scientific Reports Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep31263 |
| Popis: | Vitamin D is an important modulator of the immune response. It acts over several immune cell types where the Vitamin D receptor (VDR) is expressed. Due to the high relevance of this signaling pathway, several studies have investigated the possible influence of genes involved in the metabolism of Vitamin D and its receptor in different human diseases. Here, we analyzed whether four single-nucleotide polymorphisms of the VDR gene (rs731236, rs7975232, rs1544410 and rs2228570) are involved in the susceptibility to infection by Trypanosoma cruzi and/or to chronic Chagas cardiomyopathy (CCC) in a Colombian endemic population for this parasite. Our results showed that the rs2228570*A allele is associated with CCC development (P = 4.46E−03, OR = 1.51). In summary, the data presented in this report suggest that variation within the VDR gene may affect the immune response against T. cruzi, increasing the probability of cardiac complications in infected individuals. |
| Databáze: | OpenAIRE |
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