Oral Manifestations of Coronavirus Disease 2019 (COVID-19)
| Autor: | Sanderson D do Nascimento Medeiros, Ciro Dantas Soares, Fábio de Abreu Alves, Oslei Paes de Almeida, Alexandre de Oliveira Sales, Clovis Antonio Lopes Pinto, Maria Goretti Freire de Carvalho, Hélder Antônio Rebelo Pontes, Adalberto Mosqueda-Taylor, Lucas Lacerda de Souza, Juan Carlos Hernández-Guerrero |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Anosmia Disease Pathology and Forensic Medicine Tongue Humans Medicine Oral mucosa SARS-CoV-2 business.industry COVID-19 Endothelial Cells Middle Aged medicine.disease Dysgeusia Pneumonia Dyspnea medicine.anatomical_structure Severe acute respiratory syndrome-related coronavirus Surgery Anatomy medicine.symptom Chronic Inflammatory Infiltrate business Viral load |
| Zdroj: | American Journal of Surgical Pathology. 46:528-536 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000001825 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents rapid transmission and significant mortality worldwide. It is responsible for coronavirus disease 2019 (COVID-19). The disease presents diverse clinical symptoms, including fever, cough, dyspnea, and pneumonia. However, other manifestations associated with COVID-19 need to be clarified, leading specialists to an early diagnosis and better prognosis. We describe the spectrum of clinicopathologic COVID-19-related oral lesions that can be the first and/or the unique manifestation of the disease. Fourteen patients with a mean age of 58 years (range: 23 to 88 y) with oral lesions were included. All patients were confirmed to be infected with SARS-CoV-2 by reverse transcription polymerase chain reaction testing. Patients demonstrated mild symptoms, including dysgeusia, anosmia, fever, and headache. The lesions were recognized and classified into 2 groups: (1) lesions caused by ischemia and/or hemorrhage and (2) lesions secondary to inflammatory events associated with viral load. The palate was most affected (n=8), followed by the tongue (n=4), and both the lip and palate (n=2). Histologic analysis demonstrated thrombosis of small arteries and capillaries, associated with areas of hemorrhage and chronic inflammatory infiltrate. Immunohistochemistry showed positive staining for spike protein (SARS-CoV and SARS-CoV-2) and angiotensin-converting enzyme 2 in the surface epithelium, salivary glands, inflammatory cells, and endothelial cells. Although the incidence of oral lesions among patients infected with SARS-CoV-2 appears to be uncommon, these findings suggest that the oral mucosa can also be a target organ for SARS-CoV-2. |
| Databáze: | OpenAIRE |
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