Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex
| Autor: | Aisha M. Al-zahem, Maha H. Al-qunaibit, Mutasim I. Khalil |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Article Subject
Ligand lcsh:Biotechnology Organic Chemistry Nanotechnology Biochemistry Enol lcsh:QD146-197 Inorganic Chemistry chemistry.chemical_compound Octahedron chemistry lcsh:TP248.13-248.65 Mössbauer spectroscopy Proton NMR Curcumin lcsh:Inorganic chemistry Fourier transform infrared spectroscopy Cytotoxicity Nuclear chemistry Research Article |
| Zdroj: | Bioinorganic Chemistry and Applications Bioinorganic Chemistry and Applications, Vol 2013 (2013) |
| ISSN: | 1565-3633 |
| DOI: | 10.1155/2013/982423 |
| Popis: | Curcumin-Fe(III) complex was prepared from Fe(NO3)3·9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV/Vis,1H NMR, and13C NMR spectroscopy. The as-prepared product was characterized by elemental analysis, FTIR, UV, and Mössbauer spectroscopic techniques. An octahedral high-spin Fe(III) complex was obtained,δ, 0.37 mms−1; Q.S., 0.79 mms−1; no magnetic relaxation was observed at liquid N2temperature, neither reduction of Fe(III). The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron. |
| Databáze: | OpenAIRE |
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