Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life

Autor: S. Chevallier, Elisabeth Njamkepo, Véronique Abitbol, Fred Zepp, C.U. Meyer, Nicole Guiso, F. Vié le Sage, N. Clyti
Přispěvatelé: Prévention et thérapie moléculaires des maladies humaines, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Paediatric Immunology, University Hospital Mainz, Laboratoire GlaxoSmithKline [ Marly-le-Roi], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Cellular immunity
Disease
Lymphocyte Activation
Bordetella pertussis
MESH: Bordetella pertussis
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: Child
MESH: Diphtheria-Tetanus-Pertussis Vaccine
Virulence Factors
Bordetella
MESH: Polysaccharides
Bacterial
Child
Haemophilus Vaccines
Immunity
Cellular
Lymphokines
biology
Polysaccharides
Bacterial
MESH: Infant
MESH: Antibody Formation
Vaccination
Infectious Diseases
Child
Preschool
Molecular Medicine
Antibody
Bacterial Outer Membrane Proteins
Booster vaccination
[SDE.MCG]Environmental Sciences/Global Changes
Immunization
Secondary
MESH: Pertussis Toxin
MESH: Virulence Factors
Bordetella
Diphtheria-Tetanus-acellular Pertussis Vaccines
complex mixtures
MESH: Immunity
Cellular
Immune system
medicine
Humans
MESH: Immunization
Secondary
MESH: Haemophilus Vaccines
MESH: Lymphocyte Activation
Whooping cough
Bacterial Capsules
Diphtheria-Tetanus-Pertussis Vaccine
MESH: Lymphokines
MESH: Humans
General Veterinary
General Immunology and Microbiology
business.industry
MESH: Bacterial Outer Membrane Proteins
MESH: Child
Preschool
Public Health
Environmental and Occupational Health
Infant
medicine.disease
Virology
[SDE.ES]Environmental Sciences/Environmental and Society
MESH: Diphtheria-Tetanus-acellular Pertussis Vaccines
Pertussis Toxin
Humoral immunity
Immunology
Antibody Formation
biology.protein
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
business
Zdroj: Vaccine
Vaccine, 2007, 25 (8), pp.1390-7. ⟨10.1016/j.vaccine.2006.10.048⟩
Vaccine, Elsevier, 2007, 25 (8), pp.1390-7. ⟨10.1016/j.vaccine.2006.10.048⟩
ISSN: 0264-410X
Popis: Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.
Databáze: OpenAIRE
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