Cytokines suppress the shear stress-stimulated release of vasoactive peptides from human endothelial cells
| Autor: | Joe Marshall, Philippe Bodin, Pamela Milner, Geoffrey Burnstock |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Vasopressin Vasopressins Physiology Substance P Biochemistry Umbilical vein Interferon-gamma Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Internal medicine Vasoactive medicine Shear stress Humans Cells Cultured Chemistry Endothelins High flow rate Endothelium Vascular Stress Mechanical Peptides Endothelin receptor Perfusion Interleukin-1 |
| Zdroj: | Peptides. 16:1433-1438 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/0196-9781(95)02040-3 |
| Popis: | Endothelial cells from human umbilical vein perfused at 0.5 ml/min released vasopressin, endothelin, and substance P. Upon perfusion of the cells at 3.0 ml/min, the release of endothelia and vasopressin was significantly increased whereas the release of substance P was significantly decreased. Endothelial cells precultured for 24 h with interleukin-I (IL-1) and interferon-γ (IFN-γ) released more endothelin and less substance P at low flow and there was no further increase in release at high flow rate. These results suggest that cytokines suppress the normal responses of endothelial cells to increased fluid shear stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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