Sex‐ and race‐specific associations of bone mineral density with incident heart failure and its subtypes in older adults

Autor: Hans Gao, Sheena Patel, Raymond B. Fohtung, Peggy M. Cawthon, Anne B. Newman, Jane A. Cauley, Laura Carbone, Paulo H. M. Chaves, Phyllis K. Stein, Roberto Civitelli, Jorge R. Kizer
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American Geriatrics Society. 71:742-755
ISSN: 1532-5415
0002-8614
DOI: 10.1111/jgs.18121
Popis: Previous studies have suggested an association between bone mineral density (BMD) and heart failure (HF) risk that may be race-dependent.We evaluated the relationship between BMD and incident HF in a cohort of older adults, the Health, Aging, and Body Composition (Health ABC) study (n = 2835), and next performed a pooled analysis involving a second older cohort, the Cardiovascular Health Study (n = 1268). Hip BMD was measured by dual-energy X-ray absorptiometry in both cohorts and spine BMD by computed tomography in a subset from Health ABC.In Health ABC, lower BMD at the total hip was associated with higher incident HF in Black women after multivariable adjustment. Similar associations were found for BMD at the femoral neck and spine. In both cohorts, pooled analysis again revealed an association between lower total hip BMD and increased risk of HF in Black women (HR = 1.41 per 0.1-g/cmLower BMD was associated with higher risk of HF and especially HFpEF in older Black women and White men, highlighting the need for additional investigation into underlying mechanisms.
Databáze: OpenAIRE
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