Exchangeable Zinc Pool Size Reflects Form of Zinc Supplementation in Young Children and Is Not Associated with Markers of Inflammation
| Autor: | Julie M. Long, Afsana Mim Khandaker, Rahvia Alam Sthity, Jamie E. Westcott, Andrei Matveev, Robert E. Black, Janet C. King, Kazi Munisul Islam, Shams El Arifeen, Tahmeed Ahmed, M. Munirul Islam, Christine M. McDonald, Nancy F. Krebs |
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| Rok vydání: | 2022 |
| Předmět: |
Clinical Trials and Supportive Activities
Food Sciences Clinical Research Complementary and Integrative Health EZP zinc isotopes inflammation Bangladesh biomarker serum zinc Humans TX341-641 Child Preschool Nutrition Inflammation Nutrition and Dietetics Nutrition. Foods and food supply Evaluation of treatments and therapeutic interventions Zinc Child Preschool 6.1 Pharmaceuticals Dietary Supplements Powders Biomarkers Food Science |
| Zdroj: | Nutrients, vol 14, iss 3 Nutrients, Vol 14, Iss 481, p 481 (2022) Nutrients; Volume 14; Issue 3; Pages: 481 |
| Popis: | A sensitive and reliable biomarker of zinc status has yet to be identified, but observational research suggests that the exchangeable zinc pool (EZP) size may be a possible biomarker. This randomized, placebo-controlled trial aimed to compare the change in EZP size from baseline to endline in 174 children who were preventatively supplemented with 10 mg of zinc as part of a multiple micronutrient power (MNP) or as a standalone dispersible tablet for 24 weeks versus a placebo powder. The effects of systemic inflammation on EZP size were also evaluated. Zinc stable isotopes were administered intravenously to children at baseline and endline, and the EZP was measured by the urine extrapolation method. A total of 156 children completed the study with the zinc dispersible tablet group having the greatest increase in EZP (14.1 mg) over 24 weeks when compared with the MNP group (6.8 mg) (p < 0.01) or placebo group (2.0 mg) (p < 0.001). Median EZP size was not different between children with normal or elevated serum inflammatory markers. EZP size was responsive to longitudinal zinc supplementation and reflected the expected difference in bioavailability for two forms of supplementation. The apparent absence of an effect of inflammation on EZP size may offer an advantage for use as a biomarker for group comparisons between different interventions. |
| Databáze: | OpenAIRE |
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