The effects of cisplatin, an emetic agent, on behavior and plasma cortisol levels in goats
| Autor: | Yume Tsukamoto, Minami Shioya, Shoei Sugita, Masato Aoyama, Hitomi Hasegawa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cisplatin
medicine.medical_specialty Antiemetic Agent Hydrocortisone Vomiting business.industry Nausea Goats Dose dependence General Medicine Ondansetron Endocrinology Plasma cortisol Internal medicine medicine Reflex Animals medicine.symptom Emetics General Agricultural and Biological Sciences business medicine.drug |
| Zdroj: | Animal Science Journal. 92 |
| ISSN: | 1740-0929 1344-3941 |
| Popis: | Ruminants are not considered to experience nausea because they do not possess the emetic reflex. This study examined the effects of administration of cisplatin (cis-diamminedichloro platinum (II): CDDP), a common emetic agent, on the behavior of goats. In Experiment 1, adult Shiba goats received intravenous (IV) administration of CDDP. CDDP-administered goats spent a shorter time feeding (P < 0.01), lied down earlier (P < 0.01), and spent a longer period lying down (P < 0.01) than the saline-administered control goats, and sometimes, they directed their face downward and close their eyes. These behavioral responses were followed by a significant (P < 0.01) increase in plasma cortisol (Cor) levels, which indicated that goats experienced stress. The dose dependency was found in the extent of the CDDP effects. In Experiment 2, the effects of pretreatment of ondansetron (Ond), an antiemetic agent, were examined. Pretreatment of Ond extended the latency of lying (P < 0.01), shortened the time spent lying (P < 0.05), and reduced the extent of the increase in plasma Cor levels (P < 0.01). These results suggested that CDDP administration generated some state of stress in goats via the similar physiological mechanisms as emesis-caused stress in emetic species. |
| Databáze: | OpenAIRE |
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