The association between nm23 gene expression and survival in patients with sarcomas
| Autor: | Timothy J. Stephenson, C. Fisher, Robert C. Rees, M. H. Robinson, Janice A. Royds |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Adolescent Soft Tissue Neoplasms Biology Disease-Free Survival Metastasis Gene expression medicine Humans Neoplasm Metastasis Child Survival analysis Aged Monomeric GTP-Binding Proteins Aged 80 and over Sarcoma Middle Aged NM23 Nucleoside Diphosphate Kinases medicine.disease Prognosis Survival Analysis Staining Gene Expression Regulation Neoplastic Metastasis Suppressor Gene Oncology Child Preschool Nucleoside-Diphosphate Kinase biology.protein Immunohistochemistry Antibody Research Article Transcription Factors |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The relationship between the expression of nm23, a putative metastasis-suppressor gene and prognosis was determined for 88 patients with sarcomas. Immunohistochemistry using immunopurified anti-nm23 peptide antibodies was performed and the results of each case graded according to the degree of staining. Univariate and multivariate analyses were carried out to determine the prognostic significance of nm23 staining for sarcoma patients. Expression of nm23 was found to increase in line with metastatic potential in many cases but this did not reach significance for the study as a whole. However, the possibility of nm23 loss occurring in association with metastasis cannot be ruled out in some more aggressive sarcomas, as was demonstrated for six patients with low-scoring, unclassified and synovial sarcomas that had metastasized. The time to metastasis was longer for patients with grade 3 sarcomas (50-75% of tumour cells staining) than similar patients in other staining groups. These results suggest that expression of nm23 genes in sarcomas is variable and has no value as a prognostic indicator for these mesenchymal tumours. Images Figure 1 Figure 2 Figure 3 Figure 4 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|