Detection of 20 phthalate esters in breast milk by GC-MS/MS using QuEChERS extraction method
| Autor: | Ren Ren, Ji-cai Fan, Shu-Ting Wang, Quan Jin, Hua-Li He |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Health
Toxicology and Mutagenesis Phthalic Acids 010501 environmental sciences Breast milk Toxicology Quechers Diethyl phthalate 01 natural sciences Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Humans 0105 earth and related environmental sciences Detection limit Chromatography Milk Human 010401 analytical chemistry Public Health Environmental and Occupational Health Phthalate Esters General Chemistry General Medicine Diisobutyl phthalate Healthy Volunteers 0104 chemical sciences chemistry Female Gas chromatography–mass spectrometry Dimethyl phthalate Food Science |
| Zdroj: | Food additivescontaminants. Part A, Chemistry, analysis, control, exposurerisk assessment. 36(10) |
| ISSN: | 1944-0057 |
| Popis: | A detection method for 20 different phthalate esters (PAEs) in breast milk analyzed by quick, easy, cheap, effective, rugged, and safe (QuEChERS) clean-up with five internal standards and quantitative GC-MS/MS was established. This method can effectively remove interfering substances such as lipids and fatty acids from breast milk using acetonitrile as the extraction solvent and PSA/C18 as clean-up materials. The 20 PAEs had a linear range of 5.0-500.0 µg/L and recoveries of 83.3-123.3% with RSDs of 0.2-7.6% (n = 6). The method detection limits (LODs) were 0.004-1.3 µg/kg. Dimethyl phthalate (DMP), Diethyl phthalate (DEP), Diisobutyl phthalate (DIBP), Di-n-butyl phthalate (DBP) and bis(2-ethylhexyl) phthalate (DEHP) were detected in the 35 breast milk samples, with median levels of 1.2, 6.8, 7.3, 32.9 and 13.6 μg/kg, respectively, and the concentrations of 20 PAEs ranged between 0.5 and 137.3 μg/kg. This is a fast, simple, sensitive and accurate method for the detection of 20 PAEs in breast milk or dairy products. |
| Databáze: | OpenAIRE |
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