Vaginal health, endometrial thickness and changes in bone markers in postmenopausal women after 6 months of treatment with ospemifene in real clinical practice
| Autor: | Pilar de Lafuente, Silvia Poyo Torcal, Helena López Verdú, Carmen Pingarron, Santiago Palacios, María Sol Martínez García |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Vaginal health Endocrinology Diabetes and Metabolism Vulvovaginal atrophy Bone and Bones Endometrium chemistry.chemical_compound Endocrinology Ospemifene Humans Medicine Prospective Studies Bone Resorption Ultrasonography Postmenopausal women business.industry Obstetrics Bone markers Obstetrics and Gynecology Postmenopause Clinical Practice Tamoxifen chemistry Vagina Female sense organs business Biomarkers |
| Zdroj: | Gynecological Endocrinology. 38:78-82 |
| ISSN: | 1473-0766 0951-3590 |
| DOI: | 10.1080/09513590.2021.1970740 |
| Popis: | To assess vaginal health, endometrial thickness, and changes in bone markers in postmenopausal women with vulvovaginal atrophy (VVA) treated with 60 mg/day of ospemifene under routine clinical practice.The AYSEX study is a Spanish observational and prospective study performed in one center in which 5 gynecologists recruited postmenopausal women with VVA in routine clinical practice treated continuously with ospemifene 60 mg/day for 12 months as an appropriate therapeutic option. This article refers to the 3- and 6-months analysis. Vaginal health was assessed by pH and using Vaginal Health Index (VHI) at baseline and 3 months later. Endometrial thickness, measured by vaginal ultrasonography, and bone resorption marker (CTx) were assessed at baseline and 6 months later.A total of 100 postmenopausal women cytologically and clinically diagnosed with VVA were included in the study. After 3 months of treatment with ospemifene, pH improved from 6.1 to 4.5 (Up to date, this is the only prospective and observational study with ospemifene in routine clinical practice conditions and confirms the results previously reported from randomized controlled clinical trials, improving VVA, not increasing endometrial thickness, and decreasing CTx levels by exerting an anti-resorptive function. |
| Databáze: | OpenAIRE |
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