HTLV-Negative and HTLV Type I-Positive Tropical Spastic Paraparesis in Northeastern Brazil
| Autor: | P. Goubau, Herwig Carton, Hsin-Fu Liu, C. M. De Castro Costa, F.M.B. Da Cunha, Jan Desmyter, Terezinha de Jesus Teixeira Santos, Anne-Mieke Vandamme |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty viruses Immunology Population White People Serology immune system diseases Virology Internal medicine Tropical spastic paraparesis Prevalence medicine Humans Spasticity education Paresis Human T-lymphotropic virus 1 education.field_of_study biology business.industry Human T-lymphotropic virus 2 virus diseases biology.organism_classification medicine.disease Paraparesis Tropical Spastic Infectious Diseases Etiology Female medicine.symptom business Brazil |
| Zdroj: | Scopus-Elsevier ResearcherID |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | A type-specific serological survey among 1042 random nonneurological outpatients in two cities in the state of Ceara (northeastern Brazil) shows a low prevalence of HTLV-I (0.34% in Fortaleza; 0.44% in Crato) and of HTLV-II (0.34% in Fortaleza; 0% in Crato). Among 62 chronic myelopathic patients seen in Fortaleza 27 patients were found with clinical features of tropical spastic paraparesis (TSP); 10 of 27 were found HTLV-I seropositive (37%; 95% confidence limits, 19-58%). Proviral genome detection by polymerase chain reaction in 5 seropositive and 12 seronegative patients confirmed the serological findings. This excludes HTLV-I or -II infection as a cause in the seronegative TSP patients. The HTLV-positive and -negative patients did not differ clinically and by history, except that seropositives had a longer mean disease duration, a female predominance, and a higher proportion of white Caucasians. In this population with low HTLV-I and HTLV-II prevalences, HTLV-negative TSP is at least as frequent as the HTLV-I-associated TSP. |
| Databáze: | OpenAIRE |
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