Chagas Disease and Coumarins: A Review of Natural and Synthetic Coumarins As Anti-Trypanosoma Cruzi Agents
| Autor: | Rômulo Faria Santos Canto, Guilherme Arraché Gonçalves, Vera Lucia Eifler-Lima, Gilsane Lino von Poser, Hugo Cerecetto |
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| Rok vydání: | 2021 |
| Předmět: |
Chagas disease
Trypanosoma cruzi Context (language use) Computational biology Biology 01 natural sciences Structure-Activity Relationship Coumarins parasitic diseases Drug Discovery medicine Humans Chagas Disease Pharmacology Biological Products Life Cycle Stages 010405 organic chemistry Tropical disease General Medicine medicine.disease biology.organism_classification Trypanocidal Agents 0104 chemical sciences 010404 medicinal & biomolecular chemistry Neglected tropical diseases |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 21:1701-1717 |
| ISSN: | 1389-5575 |
| Popis: | The complexity of Chagas disease is still a challenge in endemic regions and an emergent public health problem in non-endemic countries. The causative agent of this neglected tropical disease, Trypanosoma cruzi, is mainly transmitted by triatomine vectors and possesses multiple epidemiologically important strains. Current chemotherapeutics are outdated and their limited efficacy is one of the major reasons for treatment discontinuation. In this context, the development of novel, safe and economically accessible antichagasic drugs is required. Various classes of heterocycles and natural compounds have been described as potential antichagasic scaffolds, and coumarins are no exception. These versatile compounds have a wide spectrum of biological activities, and numerous natural and synthetic coumarins have been reported with antichagasic potential. This review aims to discuss the available literature between 2001 and 2020 regarding natural and synthetic coumarins with anti- Trypanosoma cruzi activity. Moreover, some of the studies herein comprised are dedicated to the potential of coumarins to inhibit promising targets in Trypanosoma cruzi. |
| Databáze: | OpenAIRE |
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