Voluntary binge‐patterned alcohol drinking and sex‐specific influences on monoamine‐related neurochemical signatures in the mouse gut and brain
| Autor: | Karrie M. Daniels, Peter J. Clark, Mark Lyte, Allyse Shoeman, Trevor J Buhr, Ella E Bauer |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Dopamine Gut–brain axis Hypothalamus 030508 substance abuse Medicine (miscellaneous) Alcohol abuse Biology Toxicology Binge Drinking Mice Norepinephrine 03 medical and health sciences Sex Factors 0302 clinical medicine Neurochemical Internal medicine Brain-Gut Axis Intestine Small Monoaminergic Limbic System medicine Animals Cecum Chromatography High Pressure Liquid Ethanol Brain Central Nervous System Depressants medicine.disease Neostriatum Psychiatry and Mental health Endocrinology Monoamine neurotransmitter Liver Female 0305 other medical science 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 45:996-1012 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/acer.14592 |
| Popis: | BACKGROUND Altered monoamine (i.e., serotonin, dopamine, and norepinephrine) activity following episodes of alcohol abuse plays key roles not only in the motivation to ingest ethanol, but also physiological dysfunction related to its misuse. Although monoamine activity is essential for physiological processes that require coordinated communication across the gut-brain axis (GBA), relatively little is known about how alcohol misuse may affect monoamine levels across the GBA. Therefore, we evaluated monoamine activity across the mouse gut and brain following episodes of binge-patterned ethanol drinking. METHODS Monoamine and select metabolite neurochemical concentrations were analyzed by ultra-high-performance liquid chromatography in gut and brain regions of female and male C57BL/6J mice following "Drinking in the Dark" (DID), a binge-patterned ethanol ingestion paradigm. RESULTS First, we found that alcohol access had an overall small effect on gut monoamine-related neurochemical concentrations, primarily influencing dopamine activity. Second, neurochemical patterns between the small intestine and the striatum were correlated, adding to recent evidence of modulatory activity between these areas. Third, although alcohol access robustly influenced activity in brain areas in the mesolimbic dopamine system, binge exposure also influenced monoaminergic activity in the hypothalamic region. Finally, sex differences were observed in the concentrations of neurochemicals within the gut, which was particularly pronounced in the small intestine. CONCLUSION Together, these data provide insights into the influence of alcohol abuse and biological sex on monoamine-related neurochemical changes across the GBA, which could have important implications for GBA function and dysfunction. |
| Databáze: | OpenAIRE |
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