Imaging findings of multisystem inflammatory syndrome in children associated with COVID-19

Autor: Maryam Ghadimi Mahani, Susan C. Shelmerdine, Felice D'Arco, Pablo Caro-Domínguez, Christian J. Kellenberger, Lucia Riaza-Martin, Daniel Gräfe, Olaf Neth, Carlos F. Ugas Charcape, Israel Valverde, Seema Toso, Marisol Camacho, Aurelio Secinaro, Hyun Woo Goo, María Navallas, Joost van Schuppen
Přispěvatelé: University of Zurich, Caro-Domínguez, Pablo, Radiology and Nuclear Medicine
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Abdominal pain
Pleural effusion
viruses
Multisystem inflammatory syndrome
Pericardial effusion
030218 nuclear medicine & medical imaging
law.invention
Imaging
0302 clinical medicine
law
Child
Children
Lung
Neuroradiology
virus diseases
Rash
Intensive care unit
Magnetic Resonance Imaging
Systemic Inflammatory Response Syndrome
Echocardiography
COVID-19 Nucleic Acid Testing
Child
Preschool
Original Article
Female
medicine.symptom
Radiology
Cardiac function curve
medicine.medical_specialty
610 Medicine & health
03 medical and health sciences
Internal medicine
medicine
2741 Radiology
Nuclear Medicine and Imaging
Humans
Radiology
Nuclear Medicine and imaging
2735 Pediatrics
Perinatology and Child Health
Pandemics
business.industry
SARS-CoV-2
COVID-19
biochemical phenomena
metabolism
and nutrition
medicine.disease
Coronavirus
10036 Medical Clinic
Pediatrics
Perinatology and Child Health
Pulmonary venous hypertension
business
Tomography
X-Ray Computed
030217 neurology & neurosurgery
Zdroj: Pediatric Radiology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pediatric radiology, 51(9), 1608-1620. Springer Verlag
ISSN: 1432-1998
0301-0449
Popis: [Background] A hyperinflammatory immune-mediated shock syndrome has been recognised in children exposed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19).
[Objective] To describe typical imaging findings in children with multisystem inflammatory syndrome associated with COVID-19.
[Materials and methods] During the first wave of the COVID-19 pandemic, imaging studies and clinical data from children treated for multisystem inflammatory syndrome were collected from multiple centres. Standardised case templates including demographic, biochemical and imaging information were completed by participating centres and reviewed by paediatric radiologists and paediatricians.
[Results] We included 37 children (21 boys; median age 8.0 years). Polymerase chain reaction (PCR) testing was positive for SARS-CoV-2 in 15/37 (41%) children and immunoglobulins in 13/19 children (68%). Common clinical presentations were fever (100%), abdominal pain (68%), rash (54%), conjunctivitis (38%) and cough (32%). Thirty-three children (89%) showed laboratory or imaging findings of cardiac involvement. Thirty of the 37 children (81%) required admission to the intensive care unit, with good recovery in all cases. Chest radiographs demonstrated cardiomegaly in 54% and signs of pulmonary venous hypertension/congestion in 73%. The most common chest CT abnormalities were ground-glass and interstitial opacities (83%), airspace consolidation (58%), pleural effusion (58%) and bronchial wall thickening (42%). Echocardiography revealed impaired cardiac function in half of cases (51%) and coronary artery abnormalities in 14%. Cardiac MRI showed myocardial oedema in 58%, pericardial effusion in 42% and decreased left ventricular function in 25%. Twenty children required imaging for abdominal symptoms, the commonest abnormalities being free fluid (71%) and terminal ileum wall thickening (57%). Twelve children underwent brain imaging, showing abnormalities in two cases.
[Conclusion] Children with multisystem inflammatory syndrome showed pulmonary, cardiac, abdominal and brain imaging findings, reflecting the multisystem inflammatory disease. Awareness of the imaging features of this disease is important for early diagnosis and treatment.
Databáze: OpenAIRE
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