Antiproliferative effect of peptide fractions isolated from a quality protein maize, a white hybrid maize, and their derived peptides on hepatocarcinoma human HepG2 cells
| Autor: | José T. Otero-Pappatheodorou, Oscar Aguilar, Silverio García-Lara, Margarita Ortiz-Martínez, L. Margarita López-Castillo, Elvira Gonzalez de Mejia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
HepG2 Medicine (miscellaneous) Peptide Biology Hydrolysate 03 medical and health sciences 0302 clinical medicine Albumins Genotype medicine TX341-641 Bioactive peptides chemistry.chemical_classification Nutrition and Dietetics Nutrition. Foods and food supply Albumin medicine.disease Maize White (mutation) 030104 developmental biology Biochemistry chemistry Apoptosis 030220 oncology & carcinogenesis Cancer cell Antiproliferative Liver cancer Food Science |
| Zdroj: | Journal of Functional Foods, Vol 34, Iss, Pp 36-48 (2017) |
| ISSN: | 1756-4646 |
| Popis: | Hydrolysates and peptides isolated from food proteins have shown antiproliferative effects on cancer cells. Cereals are one of the main sources of protein in the diet; among cereals, maize is the most extensively cultivated and consumed in the world. The aim was to compare the antiproliferative activity of ionic exchange peptide fractions isolated from albumin alcalase hydrolysates of white hybrid (Asgrow-773) and quality protein (CML-502) maize, and their derived peptides, using an in vitro model of human liver cancer. Fraction 10 from Asgrow-773 (IC50 = 8.9 µg/mL) was more potent (p |
| Databáze: | OpenAIRE |
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