Longitudinal changes in vascular stiffness and heart rate variability among young adults with youth-onset type 2 diabetes: results from the follow-up observational treatment options for type 2 diabetes in adolescents and youth (TODAY) study
| Autor: | Kara S. Hughan, Lorraine E. Levitt Katz, Fida Bacha, Silva A. Arslanian, Dorit Koren, Elaine M. Urbina, Jeanie B. Tryggestad, Laure El Ghormli, Samuel S. Gidding, Barbara H. Braffett, Amy S. Shah |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Type 2 diabetes Pulse Wave Analysis Article Young Adult Vascular Stiffness Endocrinology Heart Rate Risk Factors Diabetes mellitus Internal medicine Internal Medicine Humans Heart rate variability Medicine Pulse wave velocity Glycemic business.industry General Medicine medicine.disease Blood pressure Diabetes Mellitus Type 2 Cohort Arterial stiffness Cardiology Female business Follow-Up Studies |
| Zdroj: | Acta Diabetol |
| ISSN: | 1432-5233 0940-5429 |
| DOI: | 10.1007/s00592-021-01796-6 |
| Popis: | (1) To describe changes in arterial stiffness and heart rate variability (HRV) over a 5-year interval, (2) examine changes by sex and race–ethnicity, and (3) evaluate the risk factors associated with the longitudinal changes in arterial stiffness and HRV. Participants with youth-onset type 2 diabetes enrolled in the observational follow-up phase of the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial had arterial stiffness [(pulse wave velocity, augmentation index, brachial distensibility] and six indices of HRV measured 5 years apart. Multivariable linear regression models assessed risk factors associated with changes in the outcomes over time. At initial vascular assessment, the 304 participants were a mean age of 21 years, 34% male, and had a mean diabetes duration of 8 years. In more than half the cohort pulse wave velocity, augmentation index and HRV increased over 5 years (p |
| Databáze: | OpenAIRE |
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