Insulin-like growth factor I absorption in the jejunum of neonatal calves
| Autor: | G Bestetti, J W Blum, P Y Vacher |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Lysine Absorption (skin) Xylose Biology Intestinal absorption Absorption Jejunum chemistry.chemical_compound Insulin-like growth factor Mesenteric Veins Internal medicine medicine Animals Humans Insulin-Like Growth Factor I Therapeutic Irrigation Chromatography Growth factor Recombinant Proteins medicine.anatomical_structure Endocrinology chemistry Animals Newborn Pediatrics Perinatology and Child Health Colostrum Autoradiography Cattle Developmental Biology |
| Zdroj: | Biology of the neonate. 68(5) |
| ISSN: | 0006-3126 |
| Popis: | The absorption of recombinant human insulin-like growth factor I (rhIGF-I), [125I]rhIGF-I, xylose and [3H]lysine, administered into a clamped jejunal segment in anesthetized neonatal calves, was studied by measuring their appearance in the mesenteric vein draining the gut segment. Only trace amounts of IGF-I and of [125I]rhIGF-I and/or 125I were absorbed following dissolution in saline, buffer or colostrum. The absorption rate of both [3H]lysine and/or 3H and of xylose was much greater than the absorption of rhIGF-I, [125I]rhIGF-I and/or 125I but was also transient. Biological effects of ingested IGF-I in neonatal calves should barely occur as a consequence of intestinal absorption even in 1-day-old calves, known to absorb various peptides and proteins. |
| Databáze: | OpenAIRE |
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