Microsatellite polymorphism in the Heme oxygenase-1 gene promoter is associated with dermal collagen density in Japanese obese male subjects

Autor: Hiromi Sanada, Masaru Matsumoto, Junko Sugama, Ai Ibuki, Shinji Iizaka, Takeo Minematsu, Mikako Yoshida
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
HMOX1
Physiology
lcsh:Medicine
Gene Expression
Biochemistry
Body Mass Index
Diagnostic Radiology
Endocrinology
Genotype
Ultrasound Imaging
Medicine and Health Sciences
lcsh:Science
Promoter Regions
Genetic

Skin
Multidisciplinary
Radiology and Imaging
Dermis
Middle Aged
medicine.anatomical_structure
Physiological Parameters
Collagen
Anatomy
Integumentary System
Research Article
Adult
medicine.medical_specialty
Imaging Techniques
Endocrine Disorders
Research and Analysis Methods
03 medical and health sciences
Young Adult
Diagnostic Medicine
Internal medicine
medicine
Genetics
Diabetes Mellitus
Humans
Obesity
RNA
Messenger

Allele
Polymorphism
Genetic

business.industry
lcsh:R
Body Weight
Biology and Life Sciences
Proteins
Promoter
Cell Biology
medicine.disease
Heme oxygenase
Oxidative Stress
030104 developmental biology
Gene Expression Regulation
Metabolic Disorders
lcsh:Q
business
Body mass index
Collagens
Heme Oxygenase-1
Microsatellite Repeats
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0199994 (2018)
ISSN: 1932-6203
Popis: We previously reported elevated oxidative stress-related mechanical vulnerabilities of the skin as sparse distributions of hyperechoic areas. Although this helped establish a personalized skin care system to prevent skin disorders related to mechanical stress, obesity-related skin vulnerability involves individual differences. Here, we hypothesized that individual differences are caused by polymorphisms of GT repetitive sequences in the heme oxygenase1 (HMOX1) promoter region, which encodes an antioxidant enzyme. This cross-sectional study enrolled healthy male volunteers in a walking classroom aimed at weight control. Subjects with a body mass index
Databáze: OpenAIRE