High CTLA-4 expression correlates with poor prognosis in thymoma patients
| Autor: | Oliviero Marinelli, Massimo Nabissi, Maria Beatrice Morelli, Silvia Rinaldi, Daniele Tomassoni, Consuelo Amantini, Claudio Cardinali, Vittorio Paolucci, Giovanni Bernardini, Matteo Santoni, Giorgio Santoni, Francesca Morgese, Mariangela Torniai, Rossana Berardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Poor prognosis Pathology medicine.medical_specialty Thymoma chemical and pharmacologic phenomena tumor-infiltrating leukocytes (TILs) Anterior mediastinum cytotoxic T lymphocyte antigen 4 (CTLA-4) 03 medical and health sciences 0302 clinical medicine Cytotoxic T lymphocyte antigen 4 (CTLA-4) Overall survival (OS) Tumor-infiltrating leukocytes (TILs) Oncology Atypical Thymoma hemic and lymphatic diseases Medicine Pathological Messenger RNA business.industry Cancer overall survival (OS) thymoma medicine.disease 030104 developmental biology CTLA-4 030220 oncology & carcinogenesis business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Thymomas, tumors that arise from epithelial cells of the thymus gland, are the most common neoplasms of the anterior mediastinum, with an incidence rate of approximately 2.5 per million/year. Cytotoxic T Lymphocyte Antigen 4 (CTLA-4 or CD152) exerts inhibitory activity on T cells, and since its oncogenic role in the progression of different types of tumors, it has emerged as a potential therapeutic target in cancer patients. In this study, we assessed the expression of CTLA-4 both at mRNA and protein levels in paraffin embedded-tissues from patients with thymomas. Furthermore, we evaluated the relationship between CTLA-4 expression and the clinical-pathologic characteristics and prognosis in patients with thymomas. Sixty-eight patients with median age corresponding to 62 years were included in this analysis. Thymomas were classified accordingly to the WHO and Masaoka-Koga for histochemical analysis and for prognostic significance. A statistical difference was found between CTLA-4 mRNA levels in human normal thymus compared with thymoma specimens. CTLA-4 expression was statistically found to progressively increase in A, B1, B2, AB and it was maximal in B3 thymomas. According to Masaoka-Koga pathological classification, CTLA-4 expression was lower in I, IIA and IIB, and higher in invasive III and IV stages. By confocal microscopy analysis we identified the expression of CTLA-4 both in tumor cells and in CD45+ tumor-infiltrating leukocytes, mainly in B3 and AB thymomas. Finally, CTLA-4 overexpression significantly correlates with reduced overall survival in thymoma patients and in atypical thymoma subgroup, suggesting that it represents a negative prognostic factor. |
| Databáze: | OpenAIRE |
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