Cardiovascular risk factors and lifestyle behaviours in relation to longevity: a Mendelian randomization study

Autor: Susanna C. Larsson, A. J. van Ballegooijen, Stephen Burgess, S van Oort, Jwj Beulens
Přispěvatelé: Epidemiology and Data Science, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, ACS - Heart failure & arrhythmias, Nephrology, van Oort, S [0000-0002-0756-2730], van Ballegooijen, AJ [0000-0002-6400-6765], Larsson, SC [0000-0003-0118-0341], Apollo - University of Cambridge Repository
Rok vydání: 2020
Předmět:
0301 basic medicine
cardiovascular risk factors
Male
Aging
Percentile
lifestyle
media_common.quotation_subject
Longevity
Type 2 diabetes
030204 cardiovascular system & hematology
Odds
03 medical and health sciences
0302 clinical medicine
longevity
Meta-Analysis as Topic
Mendelian randomization
Internal Medicine
medicine
Humans
Cardiac and Cardiovascular Systems
Genetic Predisposition to Disease
Life Style
Genetic association
media_common
Kardiologi
business.industry
Original Articles
American Heart Association
Mendelian Randomization Analysis
medicine.disease
United States
030104 developmental biology
Blood pressure
Cardiovascular Diseases
Heart Disease Risk Factors
instrumental variable analysis
Educational Status
Original Article
Female
business
Sleep
Body mass index
Biomarkers
Demography
Zdroj: Journal of Internal Medicine, 289(2), 232-243. Wiley-Blackwell
Journal of Internal Medicine
van Oort, S, Beulens, J W J, van Ballegooijen, A J, Burgess, S & Larsson, S C 2021, ' Cardiovascular risk factors and lifestyle behaviours in relation to longevity : a Mendelian randomization study ', Journal of Internal Medicine, vol. 289, no. 2, pp. 232-243 . https://doi.org/10.1111/joim.13196
ISSN: 0954-6820
DOI: 10.17863/cam.58307
Popis: Background: The American Heart Association introduced the Life's Simple 7 initiative to improve cardiovascular health by modifying cardiovascular risk factors and lifestyle behaviours. It is unclear whether these risk factors are causally associated with longevity. Objectives: This study aimed to investigate causal associations of Life's Simple 7 modifiable risk factors, as well as sleep and education, with longevity using the two-sample Mendelian randomization design. Methods: Instrumental variables for the modifiable risk factors were obtained from large-scale genome-wide association studies. Data on longevity beyond the 90th survival percentile were extracted from a genome-wide association meta-analysis with 11,262 cases and 25,483 controls whose age at death or last contact was ≤ the 60th survival percentile. Results: Risk factors associated with a lower odds of longevity included the following: genetic liability to type 2 diabetes (OR 0.88; 95% CI: 0.84;0.92), genetically predicted systolic and diastolic blood pressure (per 1-mmHg increase: 0.96; 0.94;0.97 and 0.95; 0.93;0.97), body mass index (per 1-SD increase: 0.80; 0.74;0.86), low-density lipoprotein cholesterol (per 1-SD increase: 0.75; 0.65;0.86) and smoking initiation (0.75; 0.66;0.85). Genetically increased high-density lipoprotein cholesterol (per 1-SD increase: 1.23; 1.08;1.41) and educational level (per 1-SD increase: 1.64; 1.45;1.86) were associated with a higher odds of longevity. Fasting glucose and other lifestyle factors were not significantly associated with longevity. Conclusion: Most of the Life's Simple 7 modifiable risk factors are causally related to longevity. Prevention strategies should focus on modifying these risk factors and reducing education inequalities to improve cardiovascular health and longevity.
Databáze: OpenAIRE
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