In vivo mutagenicity evaluation of the soil fumigant 1,3-dichloropropene
| Autor: | B. Bhaskar Gollapudi, Zhongyu June Yan, Melissa Badding, Sean Gehen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis Transgene Mutant Mice Transgenic 010501 environmental sciences Pharmacology Toxicology medicine.disease_cause 01 natural sciences DNA Adducts Mice 03 medical and health sciences chemistry.chemical_compound Clastogen 1 3-Dichloropropene In vivo Hydrocarbons Chlorinated Lac Repressors Genetics medicine Animals Humans Pesticides Genetics (clinical) 030304 developmental biology 0105 earth and related environmental sciences Inhalation exposure 0303 health sciences Dose-Response Relationship Drug Mutagenicity Tests In vitro toxicology Rats Inbred F344 Rats Allyl Compounds Gene Expression Regulation chemistry Mutagenesis Mutation Genotoxicity Mutagens |
| Zdroj: | Mutagenesis. 35:437-443 |
| ISSN: | 1464-3804 0267-8357 |
| DOI: | 10.1093/mutage/geaa015 |
| Popis: | 1,3-Dichloropropene (1,3-D; CAS No. 542-75-6) is a soil fumigant used for the control of nematodes in agriculture. There is an extensive database on the genotoxicity of 1,3-D and many of the published studies are confounded by the presence of mutagenic stabilisers in the test substance. Mixed results were obtained in the in vitro assays, often due to the purity of the 1,3-D sample tested. In order to get further clarity, the mutagenic potential of 1,3-D was investigated in vivo in the transgenic Big Blue rodent models. Inhalation exposure of 150 ppm 1,3-D (×2.5 tumourigenic dose) to transgenic male B6C3F1 mice did not induce lacI mutations in either the lung (tumour target tissue) or liver. Similarly, dietary administration of 1,3-D up to 50 mg/kg/day to transgenic male Fischer 344 rats did not increase the cII mutant frequency in either the liver (tumour target) or kidney. These results, along with other available in vivo data, including the absence of DNA adducts and clastogenic/aneugenic potential, support the conclusion that 1,3-D is efficiently detoxified in vivo and, as such, does not pose a mutagenic hazard or risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|