Mechanistic Study of the Azithromycin Dosage-Form-Dependent Food Effect
| Autor: | William John Curatolo, Robert R. LaBadie, George H Foulds |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.drug_class Antibiotics Biological Availability Pharmaceutical Science Capsules Azithromycin Pharmacology Bioequivalence Dosage form Food-Drug Interactions Blood serum Pharmacokinetics medicine Humans Pharmacology (medical) Chromatography High Pressure Liquid Antibacterial agent Dosage Forms Cross-Over Studies Molecular Structure business.industry digestive oral and skin physiology Organic Chemistry Fasting bacterial infections and mycoses Bioavailability Area Under Curve Molecular Medicine Female business Biotechnology medicine.drug |
| Zdroj: | Pharmaceutical Research. 27:1361-1366 |
| ISSN: | 1573-904X 0724-8741 |
| DOI: | 10.1007/s11095-010-0126-6 |
| Popis: | Azithromycin capsules are known to exhibit a negative food effect, manifest as a decrease in azithromycin bioavailability in the fed state. Azithromycin tablets are known to be bioequivalent to capsules in the fasted state, but do not exhibit a food effect. In the present study, the involvement of gastric degradation of azithromycin to des-cladinose azithromycin (DCA) has been investigated as a possible mechanism for the observed capsule food effect.Healthy volunteers were dosed with azithromycin tablets and capsules, fasted and fed, in a four-way randomized crossover study. Serum levels of DCA were measured as a function of time post-dose. Natural log-transformed PK parameters were statistically analyzed using an ANOVA model appropriate for the study design.When capsules were dosed to fed subjects, the systemic AUC for DCA was 243% of the value observed after fasted-state dosing, and the DCA C(max) was 270% of the value observed after fasted-state dosing. When azithromycin tablets were dosed in the fasted and fed states, there was no significant difference in systemic DCA.Gastric degradation of azithromycin to DCA is the likely mechanism for the observed negative food effect observed for azithromycin capsules. This effect is not observed for tablets. These observations suggest that azithromycin capsules exhibit slow and/or delayed disintegration in the fed stomach, resulting in extended gastric residence and degradation of a portion of the gastrically retained azithromycin. |
| Databáze: | OpenAIRE |
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