Kleinhovia hospita extract alleviates experimental hepatic and renal toxicities induced by a combination of antituberculosis drugs
| Autor: | Rosany Tayeb, Yulia Yusrini Djabir, Aryadi Arsyad, Muhammad Nur Amir, Fatwa Al Fia Kamaruddin, Mufidah Murdifin, Nurul Husna Najib |
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| Rok vydání: | 2020 |
| Předmět: |
hepatotoxicity
Medicine (General) RM1-950 Pharmacology Nephrotoxicity Kleinhovia hospita chemistry.chemical_compound R5-920 kleinhovia hospita Drug Discovery medicine antituberculosis drugs Ethambutol Creatinine biology business.industry nephrotoxicity Isoniazid Pyrazinamide biology.organism_classification tuberculosis chemistry Urea Therapeutics. Pharmacology business Rifampicin medicine.drug |
| Zdroj: | Journal of HerbMed Pharmacology, Vol 10, Iss 1, Pp 102-108 (2021) |
| ISSN: | 2345-5004 |
| DOI: | 10.34172/jhp.2021.10 |
| Popis: | Introduction: Antituberculosis drugs are associated with hepatic and renal toxicities due to drug’s radical metabolites. Kleinhovia hospita L extract possesses a potent antioxidant capacity that can be beneficial in eradication of oxidative-induced cell damage. This study aimed to evaluate the effects of K. hospita hydro-alcoholic extract on biomarkers and structure changes in liver and kidney induced by a combination of antituberculosis drugs (CAD), comprising isoniazid, rifampicin, pyrazinamide and ethambutol in Wistar rats. Methods: Thirty-five male Wistar rats were assigned into one of the five groups: control, CAD, and CAD with K. hospita extract in three different doses (125, 250 and 500 mg/kg). The extract was administered three hours prior to CAD and all treatments were carried out for 28 days. Following the last day of treatment, blood samples and organs were collected for biomarker analysis and histopathological examinations. Results: Twenty-eight days of CAD treatment in rats induced marked elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), serum creatinine and urea levels compared to controls. K. hospita extract at higher doses (250 mg/kg and 500 mg/kg) significantly improved ALT, urea and creatinine levels in the rats treated with CAD (P |
| Databáze: | OpenAIRE |
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