Moclobemide compared with second-generation antidepressants in elderly people
| Autor: | M. De Vanna, A. Lorizio, Alessandro Agnoli, J. Kummer, R. Anand, P. Gentili |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Monoamine Oxidase Inhibitors Moclobemide Mianserin Double-Blind Method medicine Elderly people Humans Major depressive episode Maprotiline Depression (differential diagnoses) Aged Geriatrics Aged 80 and over Psychiatric Status Rating Scales Depressive Disorder Hamilton Rating Scale for Depression Middle Aged Antidepressive Agents Psychiatry and Mental health Anesthesia Benzamides Female medicine.symptom Psychology medicine.drug |
| Zdroj: | Acta psychiatrica Scandinavica. Supplementum. 360 |
| ISSN: | 0065-1591 |
| Popis: | Two multicentre studies are described here; the first compared moclobemide with mianserin and the second with maprotiline, both in elderly patients with a DSM-III diagnosis of major depressive episode. In the first study, 80 eligible patients were randomized to either moclobemide 300–500 mg or mianserin 75–125 mg per day for 4 weeks. Mean reduction in Hamilton Rating Scale for Depression (HRSD) score was 52% in both groups. The overall assessment of efficacy was good or very good for 60% of the patients, and tolerance was considered good or very good for 85% of the patients in both groups; no significant differences between the 2 treatments were seen. The second study comprised 39 hospitalized patients randomized to either moclobemide 150–300 mg daily or maprotiline 75–150 mg daily for 6 weeks. At the end of treatment, HRSD scores declined 85% in both groups compared with baseline. The overall assessment of efficacy was over 90% good or very good in both groups. Tolerance was rated good or very good for 80% of moclobemide and 75% of maprotiline patients; none of these results differed significantly between the groups, indicating that moclobemide is as effective in elderly patients as the 2 second-generation antidepressants. In view of the safety of moclobemide, it should be considered first-line therapy for depression in elderly people. |
| Databáze: | OpenAIRE |
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