| Autor: |
Lori J. Fisher, Peter Holland, Katherine C. Freeman-Costin, David O. Newman, Ruth M. Tappen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Canadian Geriatrics Journal |
| ISSN: |
1925-8348 |
| DOI: |
10.5770/cgj.24.540 |
| Popis: |
Background To determine the feasibility of conducting an RCT on the potential effectiveness of memantine hydrochloride in prolonging safe driving in mild AD. Methods A placebo-controlled, double blind randomized trial was conducted. Forty-three individuals ≥60 with mild AD met screening criteria and were randomized. Driving ability was measured by a standardized on-road driving test. Outcomes were driving capacity at 6 and 12 months and completion of the 12-month intervention. Results Of 43 participants randomized, 59% of the memantine group and 52% of the placebo group completed the on-road test at 12 months (p = .66). All 13 memantine group participants maintained their driving status at 12 months, whereas only 8 of the 11 placebo group participants did (p = .040, OR = 4.45). Conclusions Results provide the framework for designing a rigorous multisite clinical trial of memantine effect on maintaining driving capacity in mild AD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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