A double‐blind randomized controlled trial of management of recurrent nosebleeds in children
| Autor: | Nicholas Calder, Lyndsay Fraser, Haytham Kubba, Swee K. Kang, Tash Kunanandam, Jennifer Montgomery |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.drug_class Administration Topical Cautery law.invention Double blind Recurrent nosebleeds Double-Blind Method Randomized controlled trial Antiseptic Recurrence law medicine Humans Child Administration Intranasal Silver nitrate cautery Chi-Square Distribution Treatment regimen business.industry Chlorhexidine Infant Nasal Cream Neomycin Surgery Drug Combinations Epistaxis Treatment Outcome Otorhinolaryngology Child Preschool Anesthesia Silver Nitrate Female Active treatment business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 140:670-674 |
| ISSN: | 1097-6817 0194-5998 |
| Popis: | To establish whether a treatment regimen of silver nitrate cautery and 4 weeks of antiseptic nasal cream is superior to antiseptic cream treatment alone in the management of pediatric epistaxis.Double-blind randomized controlled trial.Children with epistaxis and visible anterior septal vessels were invited to participate. Patients were randomized to receive treatment or control. Treatment patients received silver nitrate cautery, followed by antiseptic cream for 4 weeks. Control patients received sham cautery followed by antiseptic cream for 4 weeks.A total of 109 patients were randomized and results were available for 93 (85%). Of those receiving cautery, 21 (45.7%) of 46 had no bleeding in the 4 weeks before follow-up. Of those receiving only antiseptic cream 14 (29.8%) of 47 had no bleeding. (chi(2) = 2.49; P = 0.114). More children in the active treatment group had an improvement in their symptoms compared with controls (42 of 46; 91.3%) in the treatment group vs 33 of 47 (70.2%) controls (chi(2) = 6.626; P = 0.01; relative risk reduction = 71 percent, number needed to treat = 4.7).When using subjective improvement in symptoms as the outcome measure, silver nitrate cautery with antiseptic cream twice daily for 4 weeks appears to give a small but statistically significant benefit when compared to antiseptic cream alone. |
| Databáze: | OpenAIRE |
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