Development of pyridine-containing macrocyclic copper(II) complexes: potential role in the redox modulation of oxaliplatin toxicity in human breast cells
| Autor: | Ana Fernandes, Maria Fátima Cabral, Nuno Oliveira, Madalena Cipriano, Jose Rueff, Judite Costa, Jorge Gaspar, Matilde Castro |
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| Rok vydání: | 2012 |
| Předmět: |
Macrocyclic Compounds
Organoplatinum Compounds Cell Survival Pyridines Stereochemistry Antineoplastic Agents Biochemistry Redox Structure-Activity Relationship chemistry.chemical_compound Superoxides Organometallic Compounds Tumor Cells Cultured medicine Humans Cytotoxic T cell Superoxide dismutase mimetics skin and connective tissue diseases Cytotoxicity Cell Proliferation Dose-Response Relationship Drug Molecular Structure Hydroxyl Radical Superoxide Free Radical Scavengers General Medicine Hydrogen-Ion Concentration Combinatorial chemistry Oxaliplatin chemistry Cancer cell Thermodynamics Drug Screening Assays Antitumor Breast carcinoma Oxidation-Reduction Copper medicine.drug |
| Zdroj: | Free Radical Research. 46:1157-1166 |
| ISSN: | 1029-2470 1071-5762 |
| Popis: | The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1–CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied as a modulator of the cytotoxicity of oxaliplatin in epithelial breast MCF10A cells and in MCF7 breast cancer cells. Our results show that CuL3 enhances the therapeutic window of oxaliplatin, by both protecting non-tumour cells and increasing its cytotoxic effect in breast carcinoma cells. CuL3 is thus a promising complex to be further studied and to be used as a lead compound for the optimization of novel chemotherapy sensitizers. |
| Databáze: | OpenAIRE |
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