Acute Regional Myocardial Ischemia and Recovery After Cardiopulmonary Bypass: Effects of Intensity of Antecedent Ischemia
| Autor: | Jeff Johns, Betty E. Smith, Robert L McRae, Clarence P. Huggins, William D. White, Bruce J. Leone |
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| Rok vydání: | 1995 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Myocardial ischemia Ischemia Myocardial Reperfusion Injury Disease law.invention Dogs law Internal medicine Receptors Adrenergic beta Cardiopulmonary bypass Animals Ventricular Function Medicine Postoperative Period Myocardial stunning Cardiopulmonary Bypass business.industry medicine.disease Intensity (physics) medicine.anatomical_structure Anesthesia Heart Arrest Induced Cardiology Myocardial preservation Surgery Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Journal of Cardiac Surgery. 10:396-399 |
| ISSN: | 1540-8191 0886-0440 |
| DOI: | 10.1111/j.1540-8191.1995.tb00668.x |
| Popis: | Aortic cross-clamping with inadequate myocardial preservation has been shown to cause postoperative decreases in myocardial performance following coronary artery bypass graft surgery. We have demonstrated a mild decrement in myocardial beta-receptor function associated with cold cardioplegia in a normal animal model; in normal human hearts, however, response to beta-adrenergic inotropic stimulation was diminished significantly. Beta-receptor dysfunction also is associated with chronic myocardial ischemia that is associated with severe ischemic heart disease. Although the change in beta-receptor function with acute regional myocardial ischemia associated with severe ischemic heart disease is not understood fully, we found that the intensity of regional ischemia significantly affects functional recovery after cardiopulmonary bypass (CPB). Myocardial stunning does not appear to be significant in this dysfunction; however, alterations in beta-receptor density and function may play a critical role in post-CPB ventricular function. |
| Databáze: | OpenAIRE |
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