Intrathecal FMRFamide (Phe-Met-Arg-Phe-NH2) induces excessive grooming behavior in mice
| Autor: | Frank Porreca, Robert B. Raffa, Julius S. Heyman |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Atropine
Male medicine.medical_specialty Methysergide Neuropeptide (+)-Naloxone Substance P Intrathecal Mice Phentolamine Internal medicine medicine Animals FMRFamide Excessive grooming Injections Spinal Mice Inbred ICR Naloxone Chemistry General Neuroscience fungi Grooming Stimulation Chemical Endocrinology Oligopeptides medicine.drug |
| Zdroj: | Neuroscience Letters. 65:94-98 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(86)90126-6 |
| Popis: | The molluscan neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) was administered intrathecally (i.t.) to mice and their behavior was monitored for 30 min. FMRFamide induced a dramatic and dose-related (5-12 micrograms) increase in grooming-related activities compared to saline-treated controls. The grooming behavior produced by 8 micrograms FMRFamide was not blocked by simultaneous i.t. administration of 10 micrograms of the following antagonists: atropine, phentolamine, methysergide, naloxone or spantide; peripheral administration of naloxone (3.5 mg/kg, s.c.) also failed to antagonize FMRFamide grooming. These data constitute the first report that FMRFamide produces behavioral changes in mammals. |
| Databáze: | OpenAIRE |
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