Risk of developing major depression and bipolar disorder among adolescents with atopic diseases: A nationwide longitudinal study in Taiwan
| Autor: | Kai Lin Huang, Tung Ping Su, Tzeng Ji Chen, Ya Mei Bai, Han Ting Wei, Mu Hong Chen, Cheng Ta Li, Wen Hsuan Lan, Ju Wei Hsu, Wei Chen Lin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Longitudinal study Bipolar Disorder Adolescent Databases Factual National Health Programs Taiwan Comorbidity Dermatitis Atopic Atopy 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Bipolar disorder Longitudinal Studies Psychiatry Depression (differential diagnoses) Depressive Disorder Major business.industry Mood Disorders medicine.disease 030227 psychiatry body regions Psychiatry and Mental health Clinical Psychology Increased risk National health insurance Mood disorders Adolescent Behavior Cohort Female business 030217 neurology & neurosurgery |
| Zdroj: | Journal of affective disorders. 203 |
| ISSN: | 1573-2517 |
| Popis: | Backgrounds Previous studies have found an increased prevalence of atopic diseases among patients with major depression and bipolar disorder. But the temporal association between atopic diseases in adolescence and the subsequent risk of developing mood disorders has been rarely investigated. Methods Using the Taiwan National Health Insurance Research Databases, 5075 adolescents with atopic diseases (atopic cohort) and 44,729 without (non-atopic cohort) aged between 10 and 17 in 2000 were enrolled into our study and followed to the end of 2010. Subjects who developed major depression or bipolar disorder during the follow-up were identified. Results The atopic cohort had an increased risk of developing major depression (HR: 2.45, 95% CI: 1.93~3.11) and bipolar disorder (HR: 2.51, 95% CI: 1.71~3.67) compared to the non-atopic cohort, with a dose-dependent relationship between having a greater number of atopic comorbidities and a greater likelihood of major depression (1 atopic disease: HR: 1.80, 95% CI: 1.29~2.50; 2 atopic comorbidities: HR: 2.42, 95% CI: 1.93~3.04;≥3 atopic comorbidities: HR: 3.79, 95% CI: 3.05~4.72) and bipolar disorder (HR: 1.40, 95% CI: 0.57~3.44; HR: 2.81, 95% CI: 1.68~4.68; HR: 3.02, 95% CI: 1.69~5.38). Discussion Having atopic diseases in adolescence increased the risk of developing major depression and bipolar disorder in later life. Further studies may be required to clarify the underlying mechanism between atopy and mood disorders, and to investigate whether prompt intervention may decrease the risk of subsequent mood disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect