A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer’s Disease
| Autor: | Claudiu T. Supuran, Gustavo Provensi, Silvia Fossati, Fiorella Casamenti, M. Beatrice Passani, Fabrizio Carta, Alessio Nocentini |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Central Nervous System
cognition aging mitochondria neurodegenerative diseases oxidative stress Drug Evaluation Preclinical Review Disease Bioinformatics Catalysis lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Animals Humans Medicine Molecular Targeted Therapy Physical and Theoretical Chemistry Carbonic Anhydrase Inhibitors lcsh:QH301-705.5 Molecular Biology Spectroscopy Carbonic Anhydrases 030304 developmental biology 0303 health sciences business.industry Organic Chemistry Neurodegeneration Neurodegenerative Diseases General Medicine medicine.disease 3. Good health Computer Science Applications Disease Models Animal Oxidative Stress lcsh:Biology (General) lcsh:QD1-999 Gene Expression Regulation Disease Susceptibility business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 20, Iss 19, p 4724 (2019) |
| ISSN: | 1422-0067 |
| Popis: | The increase in the incidence of neurodegenerative diseases, in particular Alzheimer’s Disease (AD), is a consequence of the world′s population aging but unfortunately, existing treatments are only effective at delaying some of the symptoms and for a limited time. Despite huge efforts by both academic researchers and pharmaceutical companies, no disease-modifying drugs have been brought to the market in the last decades. Recently, several studies shed light on Carbonic Anhydrases (CAs, EC 4.2.1.1) as possible new targets for AD treatment. In the present review we summarized preclinical and clinical findings regarding the role of CAs and their inhibitors/activators on cognition, aging and neurodegeneration and we discuss future challenges and opportunities in the field. |
| Databáze: | OpenAIRE |
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