Quantification of total tannin, flavonoid contents and pharmacognostic study of the seeds of Swietenia mahagoni (Linn.)
| Autor: | Tasmia Rahman, Samira Karim, Zubair Khalid Labu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of Coastal Life Medicine, Vol 4, Iss 12, Pp 961-964 (2016) |
| ISSN: | 2309-6152 2309-5288 |
| Popis: | Objective: To justify the folkloric use of Swietenia mahagoni (S. mahagoni) seeds, 90% ethanolic extract and their aqueous and organic partitioning substances were evaluated for their possible antidiarrhoeal and antimicrobial potentials in vivo. Methods: Crude ethanolic extract of S. mahagoni seeds were subjected and partitioned into fractions using solvents at different polarity. Antimicrobial and antidiarrheal activities were evaluated and subsequently outcomes were corresponded with the conventional standard drugs. Results: The antidiarrheal activity was assessed using mouse model, where unfractionated ethanolic extract significantly reduced, the number, onset, rate and weight of diarrheal episodes. This fraction showed the limited number of defecation episodes of 27.0% and 40.9% at dose of 200 mg/kg and 400 mg/kg body weight respectively and reference drug, loperamide, showed 53% at a dose of 50 mg/kg. All extract fractions exhibited the significant potential to kill or subside the growth of known Gram-positive and Gram-negative bacteria. Conclusions: Ethanolic extract and their aqueous and organic fractious revealed the seeds of S. mahagoni (Linn.) have the potential to be used as a remedy for diarrhea and known pathogenic microbes which ensured the folkloric use of the seeds of S. mahagoni. |
| Databáze: | OpenAIRE |
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