Effect of intratracheal dexmedetomidine administration on recovery from general anaesthesia after gynaecological laparoscopic surgery: a randomised double-blinded study
| Autor: | Fei Wang, Zhenping Li, Haoxiang Zhong, Weiping Sha, Chaojin Chen, Zhuomei Huang, Caili Li, Xiaoyan Xie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Bradycardia
Laparoscopic surgery Adult China Adolescent Visual analogue scale Heart block medicine.medical_treatment Anesthesia General law.invention Anaesthesia 03 medical and health sciences Heart disorder Young Adult 0302 clinical medicine Gynecologic Surgical Procedures Randomized controlled trial Double-Blind Method 030202 anesthesiology law Germany medicine Humans General anaesthesia 030212 general & internal medicine Prospective Studies Dexmedetomidine laryngeal response Netherlands business.industry Research dexmedetomidine General Medicine Analgesics Non-Narcotic Middle Aged medicine.disease intratracheal Anesthesia Anesthesia Recovery Period Laparoscopy medicine.symptom business medicine.drug |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | Objectives To examine the efficacy of intratracheal dexmedetomidine (Dex) injection for the prevention of the laryngeal response on emergence from general anaesthesia following gynaecological laparoscopic surgery. Design Prospective, randomised, double-blinded, controlled trial. Setting A general hospital, Guangdong Province, China. Participants All patients who underwent elective laparoscopic gynaecological surgery, aged 18–60 years old, 40–80 kg in weight, American Society of Anesthesiologists class I–II were eligible. Patients were excluded if they had respiratory disease, heart disorders which might represent risk factors of potential complications of Dex such as bradycardia, heart block, coronary heart disease, uncontrolled hypertension or the long-term use of sedative drugs. Intervention Patients were randomly allocated to either receive intratracheal Dex (DT), intravenous Dex (DV) or intravenous saline (CON, n=30, respectively). In the DT and DV groups, Dex (0.5 µg/kg) was diluted and mixed in 1 or 20 mL of saline, respectively, and injected via the intratracheal or intravenous route 30 min before the completion of the surgery. Outcome measures The primary outcome was the coughing extent among the three groups. Secondary outcomes included awareness time, extubation time, postoperative visual analogue scale and Steward recovery score. Results Compared with the CON group, the extent of coughing was significantly reduced in both the DV group and the DT group. Furthermore, the mean time to awareness (13.4 (4.3) vs 8.8 (2.9), p |
| Databáze: | OpenAIRE |
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