Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese
| Autor: | Annie W.C. Kung, Kathryn C.B. Tan, Yi Han, Ching-Lung Cheung, Chor-Wing Sing, Ian C. K. Wong, Bernard M.Y. Cheung, Raymond Y.H. Leung |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Subgroup analysis 030204 cardiovascular system & hematology Risk Assessment vitamin D deficiency Brain Ischemia 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors medicine Vitamin D and neurology Electronic Health Records Humans Prospective Studies 030212 general & internal medicine Vitamin D Prospective cohort study Stroke Aged Proportional Hazards Models Chi-Square Distribution Proportional hazards model business.industry Hematology Middle Aged Prognosis Vitamin D Deficiency medicine.disease Multivariate Analysis Hong Kong Female Risk assessment business Biomarkers Cohort study |
| Zdroj: | Thrombosis and Haemostasis. 117:158-163 |
| ISSN: | 2567-689X 0340-6245 |
| Popis: | SummaryLow vitamin D levels have been associated with various cardiovascular diseases; however, whether it is associated with stroke remains inconclusive. We aimed to evaluate the association between serum 25-hydroxyvitamin D and risk of stroke. We conducted a cohort study consisting of 3,458 participants from the Hong Kong Osteoporosis Study aged ≥45 at baseline, examined between 1995 and 2010 and followed up using electronic medical records. Ischaemic and haemorrhagic stroke were defined using the ICD-9 code. In multivariable Cox-proportional hazard regression, quintiles 1 and 4 were significantly associated with increased risk of stroke when compared to the highest quintile (Quintile 1: HR, 1.78; 95 % CI, 1.16–2.74 and quintile 4: HR, 1.61; 95 % CI, 1.07–2.43). A similar association was observed in both men and women. In subgroup analysis, the association was specifically observed for ischaemic stroke, but not haemorrhagic stroke. Using a penalized regression spline, the association between vitamin D and risk of stroke was in a reverse J-shape, with the lowest risk of stroke being observed at 25(OH)D levels between 70 and 80 nmol/l. In conclusion, a low vitamin D level is associated with increased risk of ischaemic stroke; however, whether high vitamin D level is also associated with increased risk of stroke requires further study.Supplementary Material to this article is available at www.thrombosis-online.com. |
| Databáze: | OpenAIRE |
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