A new method to destruct targeted cells using magnetizable beads and pulsed magnetic force
| Autor: | Yuko Sato, S. Ueno, M. Ogiue-Ikeda |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Materials science
Cell Survival Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Radiation Dosage Ferric Compounds Biomagnetism Microsphere Magnetics Nuclear magnetic resonance Cell Line Tumor Humans Patient treatment Electrical and Electronic Engineering Radiometry Immunomagnetic Separation Dose-Response Relationship Radiation Penetration (firestop) equipment and supplies Microspheres Computer Science Applications Magnetic field Treatment Outcome Leukemia Myeloid Cell culture Magnet Biophysics Stress Mechanical human activities Biotechnology |
| Zdroj: | IEEE Transactions on Nanobioscience. 2:262-265 |
| ISSN: | 1536-1241 |
| DOI: | 10.1109/tnb.2003.820276 |
| Popis: | We investigated a new method to destruct targeted cells using magnetizable beads and pulsed magnetic force. The cells were combined with the beads by an antigen-antibody reaction (cell/bead/antibody complex), aggregated by a magnet, and stimulated by a magnetic stimulator. The viability of the aggregated and stimulated cell/bead/antibody complexes was significantly decreased, and the cells were destructed by the penetration of the beads into the cells or rupturing of the cells by the beads. These results suggest that magnetic aggregation and pulsed magnetic stimulation can effectively damage only the cells targeted by an antigen-antibody reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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