Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study
| Autor: | Kazufumi Yoshihara, Takanari Kitazono, Mao Shibata, Naoko Mukai, Yoshihiko Furuta, Masaharu Nagata, Tomoyuki Ohara, Fumio Yamashita, Toshiharu Ninomiya, Nobuyuki Sudo, Yutaka Kiyohara, Naoki Hirabayashi, Jun Hata, Seiji Gotoh |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Hippocampus 03 medical and health sciences 0302 clinical medicine Atrophy Japan Risk Factors Diabetes mellitus Internal medicine Global brain atrophy parasitic diseases Diabetes Mellitus Internal Medicine medicine Humans Hippocampus (mythology) Prospective Studies 030212 general & internal medicine Prospective cohort study Aged Aged 80 and over Advanced and Specialized Nursing medicine.diagnostic_test business.industry Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Endocrinology Postprandial Multivariate Analysis Brain size Cardiology Female Independent Living business 030217 neurology & neurosurgery |
| Zdroj: | Diabetes Care. 39:1543-1549 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc15-2800 |
| Popis: | OBJECTIVE To investigate the association between diabetes and brain or hippocampal atrophy in an elderly population. RESEARCH DESIGN AND METHODS A total of 1,238 community-dwelling Japanese subjects aged ≥65 years underwent brain MRI scans and a comprehensive health examination in 2012. Total brain volume (TBV), intracranial volume (ICV), and hippocampal volume (HV) were measured using MRI scans for each subject. We examined the associations between diabetes-related parameters and the ratios of TBV to ICV (an indicator of global brain atrophy), HV to ICV (an indicator of hippocampal atrophy), and HV to TBV (an indicator of hippocampal atrophy beyond global brain atrophy) after adjustment for other potential confounders. RESULTS The multivariable-adjusted mean values of the TBV-to-ICV, HV-to-ICV, and HV-to-TBV ratios were significantly lower in the subjects with diabetes compared with those without diabetes (77.6% vs. 78.2% for the TBV-to-ICV ratio, 0.513% vs. 0.529% for the HV-to-ICV ratio, and 0.660% vs. 0.676% for the HV-to-TBV ratio; all P < 0.01). These three ratios decreased significantly with elevated 2-h postload glucose (PG) levels (all P for trend CONCLUSIONS Our data suggest that a longer duration of diabetes and elevated 2-h PG levels, a marker of postprandial hyperglycemia, are risk factors for brain atrophy, particularly hippocampal atrophy. |
| Databáze: | OpenAIRE |
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