Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor
| Autor: | Satoru Egawa, Alexandra G. Wirth, Markandey M. Tripathi, Diane M. Tshikudi, Seemantini K. Nadkarni, Elizabeth M. Van Cott |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Science Biosensing Techniques 030204 cardiovascular system & hematology 01 natural sciences Article 010309 optics 03 medical and health sciences Speckle pattern 0302 clinical medicine 0103 physical sciences medicine Coagulation testing Humans Thromboplastin International Normalized Ratio Blood Coagulation Whole blood Prothrombin time Multidisciplinary medicine.diagnostic_test business.industry Lasers fungi Reproducibility of Results medicine.disease Thrombosis 3. Good health Surgery Hemorheology Prothrombin Time Medicine Blood Coagulation Tests business Clinical evaluation Biomedical engineering |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-017-08693-5 |
| Popis: | Prothrombin time (PT) and the associated international normalized ratio (INR) are routinely tested to assess the risk of bleeding or thrombosis and to monitor response to anticoagulant therapy in patients. To measure PT/INR, conventional coagulation testing (CCT) is performed, which is time-consuming and requires the separation of cellular components from whole blood. Here, we report on a portable and battery-operated optical sensor that can rapidly quantify PT/INR within seconds by measuring alterations in the viscoelastic properties of a drop of whole blood following activation of coagulation with thromboplastin. In this study, PT/INR values were measured in 60 patients using the optical sensor and compared with the corresponding CCT values. Our results report a close correlation and high concordance between PT/INR measured using the two approaches. These findings confirm the accuracy of our optical sensing approach for rapid PT/INR testing in whole blood and highlight the potential for use at the point-of-care or for patient self-testing. |
| Databáze: | OpenAIRE |
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