Birthweight and all-cause mortality after childhood and adolescent leukemia: a cohort of children with leukemia from Denmark, Norway, Sweden, and Washington State
Autor: | Gunnar Larfors, Ingrid Glimelius, Anne Gulbech Ording, Rebecca Troisi, Karin E. Smedby, Tom Grotmol, Anders Ekbom, Lotte Brix Christensen, David R. Doody, Steinar Tretli, Beth A. Mueller, Henrik Toft Sørensen, Tone Bjørge |
---|---|
Rok vydání: | 2020 |
Předmět: |
Male
Pediatrics Denmark 030218 nuclear medicine & medical imaging Cohort Studies 0302 clinical medicine Cause of Death Birth Weight Registries Young adult Child GESTATIONAL-AGE reproductive and urinary physiology Cause of death RISK Norway Incidence Incidence (epidemiology) Age Factors Hematology General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma CANCER Leukemia Oncology Child Preschool 030220 oncology & carcinogenesis Infant Small for Gestational Age Cohort SURVIVAL GROWTH Female Cohort study Washington medicine.medical_specialty Adolescent Birth weight Gestational Age Article Young Adult 03 medical and health sciences Sex Factors COMPLETENESS SURVEILLANCE medicine Humans Radiology Nuclear Medicine and imaging Proportional Hazards Models Sweden business.industry Infant Newborn Infant medicine.disease REGISTRY PATTERNS Small for gestational age Down Syndrome business |
Zdroj: | Ording, A G, Christensen, L B, Bjørge, T, Doody, D R, Ekbom, A, Glimelius, I, Grotmol, T, Larfors, G, Mueller, B A, Smedby, K E, Tretli, S, Troisi, R & Sørensen, H T 2020, ' Birthweight and all-cause mortality after childhood and adolescent leukemia : a cohort of children with leukemia from Denmark, Norway, Sweden, and Washington State ', Acta Oncologica, vol. 59, no. 8, pp. 949-958 . https://doi.org/10.1080/0284186X.2020.1738546 Acta Oncol |
DOI: | 10.6084/m9.figshare.11985279.v1 |
Popis: | Background: High birthweight may predispose children to acute lymphoid leukemia, whereas low birthweight is associated with childhood morbidity and mortality. Low and high birthweight have been inconsistently associated with mortality in children with leukemia. Material and methods: In a cohort of childhood and adolescent leukemia (0–19 years) patients from registries in Denmark, Norway, Sweden, and Washington State in the United States (1967–2015), five-year all-cause mortality was assessed by birthweight and other measures of fetal growth using the cumulative incidence function and Cox regression with adjustment for sex, diagnosis year, country, the presence of Down’s syndrome or other malformations, and type of leukemia. Results: Among 7148 children and adolescents with leukemia (55% male), 4.6% were low (1–2 years old; 1.0 (95% CI: 0.6, 1.5) for 3–8 years old; 1.0 (95% CI: 0.6, 1.8) for 9–13 years old; and 1.2 (95% CI: 0.7, 2.1) for 14–19 years old, and were similar for size for gestational age and Ponderal index. In analyses restricted to children born full term (37–41 weeks of gestation), results were only slightly attenuated but risk was markedly increased for infants aged ≤1 year (HR for low birthweight = 3.2, 95% CI: 1.2, 8.8). Conclusion: This cohort study does not suggest that low birthweight or SGA is associated with increased five-year all-cause mortality risk among children with any type of childhood leukemia or acute lymphoblastic leukemia, specifically, beyond infancy. |
Databáze: | OpenAIRE |
Externí odkaz: |