Evolutionary history of Leishmania killicki (synonymous Leishmania tropica) and taxonomic implications

Autor: Jean-Pierre Dedet, Anne-Laure Bañuls, Francine Pratlong, Dhekra Chaara, Loïc Talignani, Najoua Haouas, Fouad El Baidouri, Hamouda Babba, Patrick Lami, Kaouther Jaouadi, Christophe Ravel, Zoubir Harrat
Přispěvatelé: Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Biologie, Génétique et Pathologie des Pathogènes Eucaryotes (MIVEGEC-BioGEPPE), Pathogènes, Environnement, Santé Humaine (EPATH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Du gène à l'écosystème (MIVEGEC-GeneSys), Université de Monastir - University of Monastir (UM), Virostyle (MIVEGEC-Virostyle), Perturbations, Evolution, Virulence (PEV), Institut Pasteur d'Algérie, Réseau International des Instituts Pasteur (RIIP), This study was funded by the Institut Français de Coopération de Tunisie fellowship for PhD students.
Rok vydání: 2015
Předmět:
MESH: Sequence Analysis
DNA
Entomology
Leishmania tropica
Genotype
Molecular Sequence Data
C111 Parasitology
Leishmaniasis
Cutaneous
C170 Population Biology
Biology
Leishmania killicki
MESH: Phenotype
Evolution
Molecular
MESH: Genotype
Evolutionary history
Cutaneous leishmaniasis
Phylogenetics
parasitic diseases
medicine
Humans
Phylogeny
MESH: Evolution
Molecular
MESH: Leishmania tropica/classification
MESH: Leishmaniasis
Cutaneous/parasitology
Genetics
MESH: Humans
MESH: Molecular Sequence Data
MESH: Leishmania tropica/isolation & purification
Phylogenetic tree
Research
C182 Evolution
Sequence Analysis
DNA
medicine.disease
biology.organism_classification
MESH: Leishmania tropica/enzymologyA
Enzymes
Phenotype
MESH: Multilocus Sequence Typing
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Infectious Diseases
Taxon
Isoenzymatic polymorphism
Multilocus sequence typing
Parasitology
Multilocus Sequence Typing
MESH: Enzymes/analysis
Founder effect
Zdroj: Parasites & Vectors
Parasites & Vectors, 2015, 8 (1), pp.198. ⟨10.1186/s13071-015-0821-6⟩
Parasites and Vectors
Parasites and Vectors, BioMed Central, 2015, 8 (1), pp.198. ⟨10.1186/s13071-015-0821-6⟩
ISSN: 1756-3305
DOI: 10.1186/s13071-015-0821-6
Popis: International audience; BACKGROUND : The taxonomic status of Leishmania (L.) killicki, a parasite that causes chronic cutaneous leishmaniasis, is not well defined yet. Indeed, some researchers suggested that this taxon could be included in the L. tropica complex, whereas others considered it as a distinct phylogenetic complex. To try to solve this taxonomic issue we carried out a detailed study on the evolutionary history of L. killicki relative to L. tropica.METHODS : Thirty-five L. killicki and 25 L. tropica strains isolated from humans and originating from several countries were characterized using the MultiLocus Enzyme Electrophoresis (MLEE) and the MultiLocus Sequence Typing (MLST) approaches.RESULTS : The results of the genetic and phylogenetic analyses strongly support the hypothesis that L. killicki belongs to the L. tropica complex. Our data suggest that L. killicki emerged from a single founder event and that it evolved independently from L. tropica. However, they do not validate the hypothesis that L. killicki is a distinct complex. Therefore, we suggest naming this taxon L. killicki (synonymous L. tropica) until further epidemiological and phylogenetic studies justify the L. killicki denomination.CONCLUSIONS : This study provides taxonomic and phylogenetic information on L. killicki and improves our knowledge on the evolutionary history of this taxon.
Databáze: OpenAIRE
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