Hemodynamic Effects of Intravenous Midazolam-Xylazine-Butorphanol in Dogs
| Autor: | W. A. Olson, G. J. Benson, M. E. Gross, John C. Thurmon, William J. Tranquilli |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Xylazine Mean arterial pressure Cardiac output Central Venous Pressure Butorphanol Midazolam Thiazines Blood Pressure Electrocardiography Dogs Heart Rate medicine Animals Pulmonary Wedge Pressure Cardiac Output Pulmonary wedge pressure General Veterinary business.industry Hemodynamics Central venous pressure Electroencephalography Stroke Volume Stroke volume Drug Combinations medicine.anatomical_structure Blood pressure Morphinans Anesthesia Injections Intravenous Vascular resistance Female Vascular Resistance business medicine.drug |
| Zdroj: | Veterinary Surgery. 19:173-180 |
| ISSN: | 1532-950X 0161-3499 |
| DOI: | 10.1111/j.1532-950x.1990.tb01163.x |
| Popis: | The hemodynamic effects of a mixture of midazolam (1.0 mg/kg), xylazine (0.44 mg/kg), and butorphanol (0.1 mg/kg) were evaluated in six adult dogs. The dogs were anesthetized with isoflurane for instrumentation. As the dogs returned to consciousness, baseline values were recorded and the midazolam-xylazine-butorphanol mixture and glycopyrrolate (0.01 mg/kg) were administered intravenously (IV). Hemodynamic data were recorded 3, 10, 20, 30, 40, 50, and 60 minutes after injection. Mean arterial pressure (AP), mean pulmonary arterial pressure (PAP), heart rate (HR), rate-pressure product (RPP), mean pulmonary capillary wedge pressure (PCWP), systemic vascular resistance (SVR), and right ventricular stroke work index (RVSWI) were increased significantly above baseline values. Cardiac output (CO), stroke volume (SV), cardiac index (CI), stroke index (SI), mean central venous pressure (CVP), and left ventricular stroke work index (LVSWI) were decreased significantly below baseline values. When administered IV at the dosages used in this study, midazolam-xylazine-butorphanol-glycopyrrolate induced profound acute alterations in several critical hemodynamic variables. |
| Databáze: | OpenAIRE |
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