A grading dilemma; Gleason scoring system: Are we sufficiently compatible? A multi center study
| Autor: | Sumeyye Ekmekci, Özgür İlhan Çelik, Fatma Pehlivan, Nil Culhaci, Serkan Yaşar Çelik, Anıl Ağalar, Hasan Deliktaş, Gozde Evcim, Yelda Dere |
|---|---|
| Přispěvatelé: | MÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Dere, Yelda, Çelik, Özgür İlhan, Çelik, Serkan Yaşar |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Scoring system interobserver variability Turkey Gleason Score lcsh:QR1-502 Adenocarcinoma lcsh:Microbiology Pathology and Forensic Medicine Surgical pathology Prostate cancer medicine lcsh:Pathology gleason score Humans Grading (education) Observer Variation Interobserver Variability business.industry Prostate Cancer Histological Techniques Prostatic Neoplasms Reproducibility of Results General Medicine medicine.disease prostate cancer Prognosis Pathologists surgical procedures operative Multi center study Total Gleason Score Radiology Neoplasm Grading business Primary Gleason Pattern Kappa lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 63, Iss 5, Pp 25-29 (2020) |
| Popis: | WOS: 000567539300006 PubMed ID: 32108622 Objective: Gleason scoring is the grading system which strongly predicts the prognosis of prostate cancer. However, even being one of the most commonly used systems, the presence of different interobserver agreement rates push the uropathologists update the definitons of the Gleason patterns. In this study, we aimed to determine the interobserver agreement variability among 7 general pathologists, and one expert uropathologist from 6 different centers. Methods: A set of 50 Hematoxylin & Eosin stained slides from 41 patients diagnosed as prostate cancer were revised by 8 different pathologists. The pathologists were also grouped according to having their residency at the same institute or working at the same center. All pathologists' and the subgroups' Gleason scores were then compared for interobserver variability by Fleiss' and Cohen's kappa tests using R v3.2.4. Results: There were about 8 pathologists from 6 different centers revised all the slides. One of them was an expert uropathologist with experience of 18 years. Among 7 general pathologists 4 had surgical pathology experience for over 5 years whilst 3 had under 5 years. The Fleiss' kappa was found as 0.54 for primary Gleason pattern, and 0.44 for total Gleason score (moderate agreement). The Fleiss' kappa was 0.45 for grade grouping system. Conclusion: Assigning a Gleason score for a patient can be problematic because of different interobserver agreement rates among pathologists even though the patterns were accepted as well-defined. Scientific Research Projects Management Unit of Mugla Sitki Kocman UniversityMugla Sitki Kocman University [15/086] This study was supported by a Project from the Scientific Research Projects Management Unit of Mugla Sitki Kocman University (Grant number: 15/086). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|